Not being able to Install or Start the applicaiton is likely to be a problem with the ClickOnce Application Cache. In order to clear the cache try the following steps which work most of the time, also make sure you run the installer with admin privileges.

Be sure all instances of the program are closed by killing all Redefined_ManagR processes in Task Manager (Ctrl+Shift+Esc)
Uninstall the program

• Hold down the Windows Key and R
• Type or Copy appwiz.cpl in the run dialog and hit Enter
• Then try uninstalling the application

Clear Cache method

• Hold down the Windows Key and R
• Type or Copy rundll32 %SystemRoot%\system32\dfshim.dll CleanOnlineAppCache in the run dialog and hit Enter
• Then try installing the application making sure you run the installer with admin privileges

Delete the ClickOnce Application folder

• Hold down the Windows Key and R
• Type or Copy %LocalAppData%\Apps\2.0 OR %USERPROFILE%\Local Settings\Apps\2.0 in the run dialog and hit Enter
• Go inside all folders in there and remove any "rede...+ExtraRandomCharacters" folders you find e.g.: \GNR52N2B.H94 \0P3OXG7D.G79 \rede...exe_4dc51647e5727c27_0004 \Data \CHEXPMAZ.BCN \HN3LP39Z.KCR \rede..tion_4dc51647e5727c27_0004

Latest ManageR version: v4.3.6.10 ⇒ 02-05-2020 09:56

[f] Collect Challenge tokens - crash when missing characters on server

v4.3.6.9 ⇒ 01-05-2020 17:21
[f] General - Showing error when there was none (e.g.: PvE - ERR: No Errors)
[f] Collect Challenge tokens - showing wrong Character collector
[f] Collect Challenge tokens - log showing twice

v4.3.6.8 ⇒ 26-04-2020 18:14
[f] RaideR - Captcha - fixed erroring on form raid due to ow structure changes
[f] RaideR - fixed erroring on launch raid when less than minimum joiners in
[f] Collect Challenge tokens - was adding to scheduler when already added - will now check before adding

[^] Collect Challenge tokens - will not collect for ALL servers
[^] UI Changed to create more space for characters' status
[^] Added more info on Auto Login
[^] Anonymized data used to authenticate and validate users @odin
[^] Optimizations and Improvements

v4.3.6.7 ⇒ 27-03-2020 17:45
[f] RaideR - Captcha - Fixed windows losing focus during captcha in some cases
[f] RaideR - Captcha - failing to send captcha in some cases
[f] RaideR - Launch check failing
[f] RaideR - Getting Raid results
[f] Generic - Fixed issue with RGA Open in... logging out for some accounts
[f] Generic - Multicheck with ALL server name failing

[+] RaideR - Captcha - added AutoClick Ok on x characters entered

[^] Optimizations and Improvements

v4.3.6.6 ⇒ 09-02-2020 17:25
[+] PvP - Added Personal Hitlist

[f] PvE - Fixed trying multiple times to start an already finished quest
[f] Collect Challenge Tokens - Fixed error not showing for chars under level 40

[^] /!\ General - Added new Server: all which will show all OW characters at one
[^] /!\ PvE - Updated quest talk and quest finished check logic
[^] /!\ Requests Pipelined

v4.3.6.5 ⇒ 26-01-2020 09:00
[f] Skiller - Fix crash when error dialog pops-up stopping ALL skilling

[^] Skiller - Added "God Slayer" to ignore max level for now
[^] Skiller - Level Warning setting status will now be saved
[^] Generic - Changed AutoSave Characters option default to enabled

v4.3.6.4 ⇒ 25-01-2020 16:54
[+] Skiller - Added Skill Groups - prepping for PvE / Raids integration
[+] Character Info - Added current PvE Quests list - prepping for PvE integration
[+] Manager - Added Trade by Character Name
[+] Generic - Character Filter is now Saved and Loaded
[+] Generic - Do NOT Remove Last or Default Group

[f] Skiller - Fixed freeze when error dialog pops-up
[f] Skiller - Fix for freeze when no character can be skilled - pop-up error remained in background
[f] Manager - Trade by Character ID didn't take the Character ID into consideration
[f] Manager - Saving now doesn't save location and size while Maximized

[^] /!\ Generic - Reworked Save System to not overwrite and not autosave anymore, etc. - issues might appear with saving, let me know if you find something
[^] /!\ Saving - Added AutoSave Characters options (default: disabled) due to performance issues with multiple characters...
[^] Skiller - Reworked UI
[^] Manager - Collecting Challenge tokens - will not auto-change tab to scheduler
[^] UI optimizations and feedback improvements
[^] Optimizations and Improvements

[?] Many other changes

v4.3.6.3 ⇒ 06-01-2020 21:18
[+] Generic - Added Unload button which only unloads RGA and doesn't logout of OW
[+] Generic - Added Save Settings confirmation on Exit
[f] Manager - Trustee - Fixed Trustee Remove from Character list crash: Object reference not set to an instance of an object...
[f] Manager - Cauldron - Fixed Cauldron "Potion of ..." recipes missing ingredients
[f] PvE - Fixed "...can't find who drops ..." error showing step number instead of item name
[f] Generic - Fixed crashes on exit
[f] UI - fixed several UI fuckups
[^] Manager - Collecting Challenge tokens - schedule next token get in ~24 hours after successful collection
[^] UI - added quest name and step id on quest steps lists
[^] UI - added cauldron recipe ingredients list and button text as recipe type

v4.3.6.2 ⇒ 08-12-2019 17:18
[f] Scheduler - Fixed crash: Object reference not set to an instance of an object...

v4.3.6.1 ⇒ 01-12-2019 15:26
[f] Generic - ?Fixed crash: Cannot bind to the property or column...
[f] Raider - ?Fixed crash: Unable to cast object of type...
[f] Character Info - ?Fixed crash: Object reference not set to an instance of an object...
[^] Wilderness - Major overhaul - updates in progress - Status Tab and Added new Settings and Log
[^] PvE - added an extra checkbox to Spawn Rare Mobs
[^] PvE - attacking Rare mobs set to ignore filters in Rare mob is in room...
[^] PvE - removed coloring on Mobs, Areas and Quests lists
[^] UI optimizations and feedback improvements
[^] Optimizations and Improvements

v4.3.6.0 ⇒ 25-11-2019 21:35
[f] PvE - Fixed crash: Specified argument was out of the range of valid values...
[^] PvE - attacking Rare mobs set to ignore filters in Rare mob is in room... WIP